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SRPDB Bibliography

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Weiche, B., Burk, J., Angelini, S., Schiltz, E., Thumfart, J. O., and Koch, H. G. (2008)
A Cleavable N-Terminal Membrane Anchor is Involved in Membrane Binding of the Escherichia coli SRP Receptor.
J Mol Biol 377, 761-73

van Nues, R. W., Leung, E., McDonald, J. C., Dantuluru, I., and Brown, J. D. (2008)
Roles for Srp72p in assembly, nuclear export and function of the signal recognition particle. RNA Biol 5, [Epub ahead of print]

Hernandez Torres, J., Maldonado, M. A., and Chomilier, J. (2007)
Tandem duplications of a degenerated GTP-binding domain at the origin of GTPase receptors Toc159 and thylakoidal SRP.
Biochem Biophys Res Commun 364, 325-331

Siu, F. Y., Spanggord, R. J., and Doudna, J. A. (2007)
SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.
RNA 13, 240-250

Yin, J., Iakhiaeva, E., Menichelli, E., and Zwieb, C. (2007)
Identification of the RNA binding regions of SRP68/72 and SRP72 by systematic mutagenesis of human SRP RNA.
RNA Biol 4, 154-159

Yurist, S., Dahan, I., and Eichler, J. (2007)
SRP19 is a dispensable component of the signal recognition particle in Archaea.
J Bacteriol 189, 276-279

Singh, J., Dani, H. M., Sharma, R., and Steinberg, P. (2006)
Inhibition of the biosynthesis of SRP polypeptides and secretory proteins by aflatoxin B(1) can disrupt protein targeting.
Cell Biochem Funct 24, 507-510

Focia, P. J., Gawronski-Salerno, J., Coon, J. S. t., and Freymann, D. M. (2006)
Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site.
J Mol Biol 360, 631-643

Romisch, K., Miller, F. W., Dobberstein, B., and High, S. (2006)
Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages,
Arthritis Res Ther 8, R39

Raine, A., Lovmar, M., Wikberg, J., and Ehrenberg, M. (2006)
Trigger factor binding to ribosomes with nascent peptide chains of varying lengths and sequences,
J Biol Chem [Epub ahead of print]

Steiner, D., Forrer, P., Stumpp, M. T., and Pluckthun, A. (2006)
Signal sequences directing cotranslational translocation expand the range of proteins amenable to phage display,
Nat Biotechnol 24, 823-831

Bloois, E. V., Haan, G. J., Gier, J. W., Oudega, B., and Luirink, J. (2006)
Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CYOA,
J Biol Chem 281, 10002-10009

Onafuwa-Nuga, A. A., Telesnitsky, A., and King, S. R. (2006)
7SL RNA, but not the 54-kd signal recognition particle protein, is an abundant component of both infectious HIV-1 and minimal virus-like particles,
RNA 12, 542-546

Eisner, G., Moser, M., Schafer, U., Beck, K., and Muller, M. (2006)
Alternate recruitment of signal recognition particle and trigger factor to the signal sequence of a growing nascent polypeptide,
J Biol Chem 281, 7172-7179

Focia, P. J., Gawronski-Salerno, J., Coon, J. S. t., and Freymann, D. M. (2006)
Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site,
J Mol Biol 360, 631-643

Halic, M., Gartmann, M., Schlenker, O., Mielke, T., Pool, M. R., Sinning, I., and Beckmann, R. (2006)
Signal recognition particle receptor exposes the ribosomal translocon binding site,
Science 12, 467-468

Hasler, J., and Strub, K. (2006)
Alu RNP and Alu RNA regulate translation initiation in vitro,
Nucleic Acids Res 34, 2374-2385

Zanen, G., Antelmann, H., Meima, R., Jongbloed, J. D., Kolkman, M., Hecker, M., van Dijl, J. M., and Quax, W. J. (2006)
Proteomic dissection of potential signal recognition particle dependence in protein secretion by Bacillus subtilis,
Proteomics 6, 3636-3648

Klenell, M., Morita, S., Tiemblo-Olmo, M., Muhlenbock, P., Karpinski, S., and Karpinska, B. (2005)
Involvement of the chloroplast signal recognition particle cpSRP43 in acclimation to conditions promoting photooxidative stress in Arabidopsis,
Plant Cell Physiol 46, 118-129

Kuruma, Y., Nishiyama, K. I., Shimizu, Y., Muller, M., and Ueda, T. (2005)
Development of a Minimal Cell-Free Translation System for the Synthesis of Presecretory and Integral Membrane Proteins,
Biotechnol Prog 21, 1243-1251

Spanggord, R. J., Siu, F., Ke, A., and Doudna, J. A. (2005)
RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle,
Nat Struct Mol Biol 12, 1116-1122

Schaaf, A., Tintelnot, S., Baur, A., Reski, R., Gorr, G., and Decker, E. L. (2005)
Use of endogenous signal sequences for transient production and efficient secretion by moss (Physcomitrella patens) cells,
BMC Biotechnol 5, 30

Schlunzen, F., Wilson, D. N., Tian, P., Harms, J. M., McInnes, S. J., Hansen, H. A., Albrecht, R., Buerger, J., Wilbanks, S. M., and Fucini, P. (2005)
The Binding Mode of the Trigger Factor on the Ribosome: Implications for Protein Folding and SRP Interaction,
Structure (Camb) 13, 1685-1694

Halic, M., Becker, T., Frank, J., Spahn, C. M., and Beckmann, R. (2005)
Localization and dynamic behavior of ribosomal protein L30e,
Nat Struct Mol Biol 12, 467-468

Lustig, Y., Goldshmidt, H., Uliel, S., and Michaeli, S. (2005)
The Trypanosoma brucei signal recognition particle lacks the Alu-domain-binding proteins: purification and functional analysis of its binding proteins by RNAi,
J Cell Sci 118, 4551-4562

Hasona, A., Crowley, P. J., Levesque, C. M., Mair, R. W., Cvitkovitch, D. G., Bleiweis, A. S., and Brady, L. J. (2005)
Streptococcal viability and diminished stress tolerance in mutants lacking the signal recognition particle pathway or YidC2,
Proc Natl Acad Sci U S A 102, 17466-17471

Deitermann, S., Sprie, G. S., and Koch, H. G. (2005)
A dual function for SecA in the assembly of single-spanning membrane proteins in Escherichia coli,
J Biol Chem 280, 39077-39085

Buskiewicz, I., Peske, F., Wieden, H. J., Gryczynski, I., Rodnina, M. V., and Wintermeyer, W. (2005)
Conformations of the Signal Recognition Particle Protein Ffh from Escherichia coli as Determined by FRET,
J Mol Biol 351, 417-430

Buskiewicz, I., Kubarenko, A., Peske, F., Rodnina, M. V., and Wintermeyer, W. (2005)
Domain rearrangement of SRP protein Ffh upon binding 4.5S RNA and the SRP receptor FtsY,
RNA 11, 947-957

Chou, Y. T., and Gierasch, L. M. (2005)
The conformation of a signal peptide bound by Escherichia coli preprotein translocase SecA,
J Biol Chem 280, 32753-32760

Shan, S. O., and Walter, P. (2005)
Molecular Crosstalk between the Nucleotide Specificity Determinant of the SRP GTPase and the SRP Receptor,
Biochemistry 44, 6214-6222

Iakhiaeva, E., Yin, J., and Zwieb, C. (2005)
Identification of an RNA-binding Domain in Human SRP72,
J Mol Biol 345, 659-666

Shan, S. O., and Walter, P. (2005)
Co-translational protein targeting by the signal recognition particle,
FEBS Lett 579, 921-926

Singh, J., Singh, S., Dani, H. M., Sharma, R., and Steinberg, P. (2005)
Interactions of aflatoxin B1 with SRP components can disrupt protein targeting,
Cell Biochem Funct 23, 9-13

Sommerville, J., Brumwell, C. L., Politz, J. C., and Pederson, T. (2005)
Signal recognition particle assembly in relation to the function of amplified nucleoli of Xenopus oocytes,
J Cell Sci 118, 1299-1307

Hainzl, T., Huang, S., and Sauer-Eriksson, A. E. (2005)
Structural insights into SRP RNA: An induced fit mechanism for SRP assembly,
RNA 11, 1043-1050

Halic, M., and Beckmann, R. (2005)
The signal recognition particle and its interactions during protein targeting,
Curr Opin Struct Biol 15, 116-125

Houben, E. N., Zarivach, R., Oudega, B., and Luirink, J. (2005)
Early encounters of a nascent membrane protein: specificity and timing of contacts inside and outside the ribosome,
J Cell Biol

Huber, D., Boyd, D., Xia, Y., Olma, M. H., Gerstein, M., and Beckwith, J. (2005)
Use of Thioredoxin as a Reporter To Identify a Subset of Escherichia coli Signal Sequences That Promote Signal Recognition Particle-Dependent Translocation,
J Bacteriol 187, 2983-2991

Zwieb, C., Van Nues, R. W., Rosenblad, M. A., Brown, J. D., and Samuelsson, T. (2005)
A nomenclature for all signal recognition particle RNAs,
RNA 11, 7-13

Focia, P. J., Shepotinovskaya, I. V., Seidler, J. A., and Freymann, D. M. (2004)
Heterodimeric GTPase core of the SRP targeting complex,
Science 303, 373-377

Focia, P. J., Alam, H., Lu, T., Ramirez, U. D., and Freymann, D. M. (2004)
Novel protein and Mg2+ configurations in the Mg2+GDP complex of the SRP GTPase ffh,
Proteins 54, 222-230

Ferbitz, L., Maier, T., Patzelt, H., Bukau, B., Deuerling, E., and Ban, N. (2004)
Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins,
Nature 431, 590-596

Egea, P. F., Shan, S. O., Napetschnig, J., Savage, D. F., Walter, P., and Stroud, R. M. (2004)
Substrate twinning activates the signal recognition particle and its receptor,
Nature 427, 215-221

Abell, B. M., Pool, M. R., Schlenker, O., Sinning, I., and High, S. (2004)
Signal recognition particle mediates post-translational targeting in eukaryotes,
Embo J 23, 2755-2764

White, S. H., and von Heijne, G. (2004)
The machinery of membrane protein assembly,
Curr Opin Struct Biol 14, 397-404

Wild, K., Halic, M., Sinning, I., and Beckmann, R. (2004)
SRP meets the ribosome,
Nat Struct Mol Biol 11, 1049-1053

Wild, K., Rosendal, K. R., and Sinning, I. (2004)
A structural step into the SRP cycle,
Mol Microbiol 53, 357-363

Moll, R. G. (2004)
The archaeal signal recognition particle: steps toward membrane binding,
J Bioenerg Biomembr 36, 47-53

Chu, F., Shan, S. O., Moustakas, D. T., Alber, F., Egea, P. F., Stroud, R. M., Walter, P., and Burlingame, A. L. (2004)
Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry,
Proc Natl Acad Sci U S A 101, 16454-16459

Yi, L., Celebi, N., Chen, M., and Dalbey, R. E. (2004)
Sec/SRP requirements and energetics of membrane insertion of subunits a, b, and c of the Escherichia coli F1F0 ATP synthase,
J Biol Chem 279, 39260-39267

Terzi, L., Pool, M. R., Dobberstein, B., and Strub, K. (2004)
Signal recognition particle Alu domain occupies a defined site at the ribosomal subunit interface upon signal sequence recognition,
Biochemistry 43, 107-117

Yin, J., Huang, Q., Pakhomova, O. P., Hinck, A. P., and Zwieb, C. (2004)
The conserved adenosine in helix 6 of signal recognition particle RNA initiates SRP assembly,
Archaea 1, 269–276


Luirink, J., and Sinning, I. (2004)
SRP-mediated protein targeting: structure and function revisited,
Biochim Biophys Acta 1694, 17-35

Tyson, G. W., Chapman, J., Hugenholtz, P., Allen, E. E., Ram, R. J., Richardson, P. M., Solovyev, V. V., Rubin, E. M., Rokhsar, D. S., and Banfield, J. F. (2004)
Community structure and metabolism through reconstruction of microbial genomes from the environment,
Nature


Dobberstein, B., and Sinning, I. (2004)
Structural biology. Surprising news from the PCC,
Science 303, 320-322


Van Nues, R. W., and Brown, J. D. (2004)
Saccharomyces SRP RNA secondary structures: A conserved S-domain and extended Alu-domain,
RNA 10, 75-89


Doudna, J. A., and Batey, R. T. (2004)
Structural Insights into the Signal Recognition Particle,
Annu Rev Biochem 73, 539-557

Yin, J., Yang, C. H., and Zwieb, C. (2004)
Two strategically placed base pairs in helix 8 of mammalian signal recognition particle RNA are crucial for the SPR19-dependent binding of protein SRP54,
Rna 10, 574-580


Halic, M., Becker, T., Pool, M. R., Spahn, C. M., Grassucci, R. A., Frank, J., and Beckmann, R. (2004)
Structure of the signal recognition particle interacting with the elongation-arrested ribosome,
Nature 427, 808-814


Horwich, A. (2004)
Cell biology: sight at the end of the tunnel,
Nature 431, 520-522

Huck, L., Scherrer, A., Terzi, L., Johnson, A. E., Bernstein, H. D., Cusack, S., Weichenrieder, O., and Strub, K. (2004)
Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain,
Nucleic Acids Res 32, 4915-4924


Rosenblad, M. A., Zwieb, C., and Samuelsson, T. (2004)
Identification and comparative analysis of components from the signal recognition particle in protozoa and fungi,
BMC Genomics 5, 5


Rosendal, K. R., Sinning, I., and Wild, K. (2004)
Crystallization of the crenarchaeal SRP core,
Acta Crystallogr Section D Biol Crystallogr 60, 140-143

Sagar, M. B., Lucast, L., and Doudna, J. A. (2004)
Conserved but nonessential interaction of SRP RNA with translation factor EF-G,
Rna 10, 772-778


Buskiewicz, I., Deuerling, E., Gu, S. Q., Jockel, J., Rodnina, M. V., Bukau, B., and Wintermeyer, W. (2004)
Trigger factor binds to ribosome-signal-recognition particle (SRP) complexes and is excluded by binding of the SRP receptor,
Proc Natl Acad Sci U S A 101, 7902-7906

Shepotinovskaya, I. V., Focia, P. J., and Freymann, D. M. (2003)
Crystallization of the GMPPCP complex of the NG domains of Thermus aquaticus Ffh and FtsY,
Acta Crystallogr D Biol Crystallogr 59, 1834-1837

Rosenblad, M. A., Gorodkin, J., Knudsen, B., Zwieb, C., and Samuelsson, T. (2003)
SRPDB: Signal Recognition Particle Database,
Nucleic Acids Res 31, 363-364

Rosendal, K. R., Wild, K., Montoya, G., and Sinning, I. (2003)
Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication,
Proc Natl Acad Sci U S A 100, 14701-14706


San Miguel, M., Marrington, R., Rodger, P. M., Rodger, A., and Robinson, C. (2003)
An Escherichia coli twin-arginine signal peptide switches between helical and unstructured conformations depending on the hydrophobicity of the environment,
Eur J Biochem 270, 3345-3352

Sauer-Eriksson, A. E., and Hainzl, T. (2003)
S-domain assembly of the signal recognition particle,
Curr Opin Struct Biol 13, 64-70

Koch, H. G., Moser, M., and Muller, M. (2003)
Signal recognition particle-dependent protein targeting, universal to all kingdoms of life,
Rev Physiol Biochem Pharmacol 146, 55-94

Beha, D., Deitermann, S., Muller, M., and Koch, H. G. (2003)
Export of beta-lactamase is independent of the signal recognition particle,
J Biol Chem 278, 22161-22167

Mandon, E. C., Jiang, Y., and Gilmore, R. (2003)
Dual recognition of the ribosome and the signal recognition particle by the SRP receptor during protein targeting to the endoplasmic reticulum,
J Cell Biol 162, 575-585

Schwartz, T., and Blobel, G. (2003)
Structural basis for the function of the beta subunit of the eukaryotic signal recognition particle receptor,
Cell 112, 793-803

Frasz, C., and Arvidson, C. G. (2003)
Role for both DNA and RNA in GTP Hydrolysis by the Neisseria gonorrhoeae Signal Recognition Particle Receptor,
J Bacteriol 185, 801-808

Moll, R. G. (2003)
Protein-protein, protein-RNA and protein-lipid interactions of signal-recognition particle components in the hyperthermoacidophilic archaeon Acidianus ambivalens,
Biochem J 374, 247-254


Lerner, R. S., Seiser, R. M., Zheng, T., Lager, P. J., Reedy, M. C., Keene, J. D., and Nicchitta, C. V. (2003)
Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes,
Rna 9, 1123-1137


Peterson, J. H., Woolhead, C. A., and Bernstein, H. D. (2003)
Basic amino acids in a distinct subset of signal peptides promote interaction with the signal recognition particle,
J Biol Chem 278, 46155-46162

Gu, S. Q., Peske, F., Wieden, H. J., Rodnina, M. V., and Wintermeyer, W. (2003)
The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome,
Rna 9, 566-573

Cochrane, J. C., Batey, R. T., and Strobel, S. A. (2003)
Quantitation of free energy profiles in RNA-ligand interactions by nucleotide analog interference mapping,
Rna 9, 1282-1289


Li, Y., Cole, K., and altman, S. (2003)
The effect of a single, temperature-sensitive mutation on global gene expression in Escherichia coli,
Rna 9, 518-532

Zwieb, C. (2003)
Signal recognition particle-mediated protein targeting,
Recent Res Develop Mol Biol 1, 205-224


Liu, L., Ben-Shlomo, H., Xu, Y. X., Stern, M. Z., Goncharov, I., Zhang, Y., and Michaeli, S. (2003)
The trypanosomatid signal recognition particle consists of two RNA molecules, a 7SL RNA homologue and a novel tRNA-like molecule,
J Biol Chem 278, 18271-18280

Tyedmers, J., Lerner, M., Wiedmann, M., Volkmer, J., and Zimmermann, R. (2003)
Polypeptide-binding proteins mediate completion of co-translational protein translocation into the mammalian endoplasmic reticulum,
EMBO Rep 4, 505-510

Shepotinovskaya, I. V., and Freymann, D. M. (2002)
Conformational change of the N-domain on formation of the complex between the GTPase domains of Thermus aquaticus Ffh and FtsY,
Biochim Biophys Acta 1597,107-114

Liu, L., Liang, X. H., Uliel, S., Unger, R., Ullu, E., and Michaeli, S. (2002)
RNA interference of signal peptide-binding protein SRP54 elicits deleterious effects and protein sorting defects in trypanosomes,
J Biol Chem 277, 47348-47357

Tozik, I., Huang, Q., Zwieb, C., and Eichler, J. (2002)
Reconstitution of the signal recognition particle of the halophilic archaeon Haloferax volcanii,
Nucleic Acids Res 30, 4166-4175

Batey, R. T., and Doudna, J. A. (2002)
Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly,
Biochemistry 41, 11703-11710

Avdeeva, O. N., Myasnikov, A. G., Sergiev, P. V., Bogdanov, A. A., Brimacombe, R., and Dontsova, O. A. (2002)
Construction of the 'minimal' SRP that interacts with the translating ribosome but not with specific membrane receptors in Escherichia coli,
FEBS Lett 514, 70-73

Oubridge, C., Kuglstatter, A., Jovine, L., and Nagai, K. (2002)
Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle,
Mol Cell 9, 1251-1261

Pakhomova, O. N., Deep, S., Huang, Q., Zwieb, C., and Hinck, A. P. (2002)
Solution structure of protein SRP19 of Archaeoglobus fulgidus signal recognition particle,
J Mol Biol 317, 145-158

Wild, K., Weichenrieder, O., Strub, K., Sinning, I., and Cusack, S. (2002)
Towards the structure of the mammalian signal recognition particle,
Curr Opin Struct Biol 12, 72-81


Hainzl, T., Huang, S., and Sauer-Eriksson, A. E. (2002)
Structure of the SRP19 RNA complex and implications for signal recognition particle assembly,
Nature 417, 767-771

Herskovits, A. A., Shimoni, E., Minsky, A., and Bibi, E. (2002)
Accumulation of endoplasmic membranes and novel membrane-bound ribosome-signal recognition particle receptor complexes in Escherichia coli,
J Cell Biol 159, 403-410

Politz, J. C., Lewandowski, L. B., and Pederson, T. (2002)
Signal recognition particle RNA localization within the nucleolus differs from the classical sites of ribosome synthesis,
J Cell Biol 159, 411-418

Pool, M. R., Stumm, J., Fulga, T. A., Sinning, I., and Dobberstein, B. (2002)
Distinct modes of signal recognition particle interaction with the ribosome,
Science 297, 1345-1348

Kuglstatter, A., Oubridge, C., and Nagai, K. (2002)
Induced structural changes of 7SL RNA during the assembly of human signal recognition particle,
Nat Struct Biol 9, 740-744

Ramirez, U. D., Minasov, G., Focia, P. J., Stroud, R. M., Walter, P., Kuhn, P., and Freymann, D. M. (2002)
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh,
J Mol Biol 320, 783-799


Regalia, M., Rosenblad, M. A., and Samuelsson, T. (2002)
Prediction of signal recognition particle RNA genes,
Nucleic Acids Res 30, 3368-3377

Caetano-Anolles, G. (2002)
Evolved RNA secondary structure and the rooting of the universal tree of life,
J Mol Evol 54, 333-345


Rinke-Appel, J., Osswald, M., von Knoblauch, K., Mueller, F., Brimacombe, R., Sergiev, P., Avdeeva, O., Bogdanov, A., and Dontsova, O. (2002)
Crosslinking of 4.5S RNA to the Escherichia coli ribosome in the presence or absence of the protein Ffh,
RNA 8, 612-625


Brunelli, C. A., O'Connor, M., and Dahlberg, A. E. (2002)
Decreased requirement for 4.5S RNA in 16S and 23S rRNA mutants of Escherichia coli,
FEBS Lett 514, 44-48

Padmanabhan, S., and Freymann, D. M. (2001)
The conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPase,
Structure 9, 859-867

Dean, K. A., von Ahsen, O., Gorlich, D., and Fried, H. M. (2001)
Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin,
J Cell Sci 114, 3479-3485

Perumal, K., Sinha, K., Henning, D., and Reddy, R. (2001)
Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme,
J Biol Chem 276, 21791-21796

Yang, C. H., and Zwieb, C. (2001)
Swapping of functional domains using a chimeric monster deletion mutagenesis strategy,
Biotechniques 31, 724-728

Grosshans, H., Deinert, K., Hurt, E., and Simos, G. (2001)
Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export,
J Cell Biol 153, 745-762


Yin, J., Yang, C. H., and Zwieb, C. (2001)
Assembly of human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control,
RNA 7, 1389-1396


Herskovits, A. A., Seluanov, A., Rajsbaum, R., ten Hagen-Jongman, C. M., Henrichs, T., Bochkareva, E. S., Phillips, G. J., Probst, F. J., Nakae, T., Ehrmann, M., Luirink, J., and Bibi, E. (2001)
Evidence for coupling of membrane targeting and function of the signal recognition particle (SRP) receptor FtsY,
EMBO Rep 2, 1040-1046

Beckmann, R., Spahn, C. M., Eswar, N., Helmers, J., Penczek, P. A., Sali, A., Frank, J., and Blobel, G. (2001)
Architecture of the protein-conducting channel associated with the translating 80S ribosome,
Cell 107, 361-372

Jagath, J. R., Matassova, N. B., de Leeuw, E., Warnecke, J. M., Lentzen, G., Rodnina, M. V., Luirink, J., and Wintermeyer, W. (2001)
Important role of the tetraloop region of 4.5S RNA in SRP binding to its receptor FtsY,
RNA 7, 293-301


Maeshima, H., Okuno, E., Aimi, T., Morinaga, T., and Itoh, T. (2001)
An archaeal protein homologous to mammalian SRP54 and bacterial Ffh recognizes a highly conserved region of SRP RNA,
FEBS Lett 507, 336-340

Keenan, R. J., Freymann, D. M., Stroud, R. M., and Walter, P. (2001)
The Signal Recognition Particle,
Annu Rev Biochem 70, 755-775

Driessen, A. J., Manting, E. H., and van der Does, C. (2001)
The structural basis of protein targeting and translocation in bacteria,
Nat Struct Biol 8, 492-498

Bhuiyan, S. H., Pakhomova, O. N., Hinck, A. P., and Zwieb, C. (2001)
Complexes with truncated RNAs from the large domain of Archaeoglobus fulgidus signal recognition particle,
FEMS Microbiol Lett 198, 105-110

Ring, G., and Eichler, J. (2001)
Characterization of inverted membrane vesicles from the halophilic archaeon Haloferax volcanii,
J Membr Biol 183, 195-204

Rose, M. A., and Weeks, K. M. (2001)
Visualizing induced fit in early assembly of the human signal recognition particle,
Nat Struct Biol 8, 515-520.

Fulga, T. A., Sinning, I., Dobberstein, B., and Pool, M. R. (2001)
SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon,
Embo J 20, 2338-2347

Gorodkin, J., Knudsen, B., Zwieb, C., and Samuelsson, T. (2001)
SRPDB (Signal Recognition Particle Database),
Nucleic Acids Research 1, 169-170


Pakhomova, O. N., Cui, Y., Zwieb, C., and Hinck, A. P. (2001)
Sequence-specific 1H, 13C and 15N signal assignments and secondary structure of archaeoglobusfulgidus SRP19,
J Biomol NMR 20, 187-188

Wild, K., Sinning, I., and Cusack, S. (2001)
Crystal structure of an early protein-RNA assembly complex of the signal recognition particle,
Science 294, 598-601


Peluso, P., Shan, S. O., Nock, S., Herschlag, D., and Walter, P. (2001)
Role of SRP RNA in the GTPase cycles of Ffh and FtsY,
Biochemistry 40, 15224-15233

Peluso, P., Herschlag, D., Nock, S., Freymann, D. M., Johnson, A. E., and Walter, P. (2000)
Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor,
Science 288, 1640-1643

Neumann-Haefelin, C., Schafer, U., Muller, M., and Koch, H. G. (2000)
SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein,
Embo J 19, 6419-626.

Legate, K. R., Falcone, D., and Andrews, D. W. (2000)
Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit,
J Biol Chem 275, 27439-27446


Mason, N., Ciufo, L. F., and Brown, J. D. (2000)
Elongation arrest is a physiologically important function of signal recognition particle,
EMBO J 19, 4164-4174.

Batey, R. T., Rambo, R. P., Lucast, L., Rha, B., and Doudna, J. A. (2000)
Crystal structure of the ribonucleoprotein core of the signal recognition particle,
Science 287, 1232-1239

Politz, J. C., Yarovoi, S., Kilroy, S. M., Gowda, K., Zwieb, C., and Pederson, T. (2000)
Signal Recognition Particle Components in the Nucleolus,
Proc Natl Acad Sci U S A 97, 55-60


Bhuiyan, S. H., Gowda, K., Hotokezaka, H., and Zwieb, C. (2000)
Assembly of archaeal signal recognition particle from recombinant components,
Nucleic Acids Research 28, 1365-1373


Rupert, P. B., and Ferre-D'amare A, R. (2000)
SRPrises in RNA-protein recognition,
Structure Fold Des 8, R99-104

Chin, C. N., and von Heijne, G. (2000)
Charge pair interactions in a model transmembrane helix in the ER membrane,
J Mol Biol 303, 1-5


Herskovits, A. A., and Bibi, E. (2000)
Association of Escherichia coli ribosomes with the inner membrane requires the signal recognition particle receptor but is independent of the signal recognition particle,
Proc Natl Acad Sci U S A 97, 4621-4626.

Herskovits, A. A., Bochkareva, E. S., and Bibi, E. (2000)
New prospects in studying the bacterial signal recognition particle pathway,
Mol Microbiol 38, 927-939

Montoya, G., Kaat, K., Moll, R., Schafer, G., and Sinning, I. (2000)
The crystal structure of the conserved GTPase of SRP54 from the archaeon Acidianus ambivalens and its comparison with related structures suggests a model for the SRP-SRP receptor complex,
Structure Fold Des 8, 515-525

Jovine, L., Hainzl, T., Oubridge, C., Scott, W. G., Li, J., Sixma, T. K., Wonacott, A., Skarzynski, T., and Nagai, K. (2000)
Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA,
Structure Fold Des 8, 527-540

Eichler, J. (2000)
Archaeal protein translocation,
Eur J Biochem 267, 3402-3412.

Walter, P., Keenan, R., and Schmitz, U. (2000)
Perspectives: structural biology. SRP--where the RNA and membrane worlds meet,
Science 287, 1212-123.

Zwieb, C., and Samuelsson, T. (2000)
SRPDB (Signal Recognition Particle Database),
Nucleic Acids Research 28, 171-172


Diener, J. L., and Wilson, C. (2000)
Role of SRP19 in assembly of the archaeoglobus fulgidus signal recognition particle,
Biochemistry 39, 12862-12874

Jovine, L., Hainzl, T., Oubridge, C., and Nagai, K. (2000)
Crystallization and preliminary X-ray analysis of the conserved domain IV of Escherichia coli 4.5S RNA. erratum,
Acta Crystallogr D Biol Crystallogr 56, 1512

Weichenrieder, O., Wild, K., Strub, K., and Cusack, S. (2000)
Structure and assembly of the Alu domain of the mammalian signal recognition particle,
Nature 408, 167-73.

Suzuma, S., Hayashi, K., Nakamura, K., and Yamane, K. (1999)
Analysis of Escherichia coli 4.5S RNA binding affinity to Ffh and EF-G,
FEMS Microbiol Lett 180, 271-277


Bacher, G., Pool, M., and Dobberstein, B. (1999)
The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor,
J Cell Biol 146, 723-730

Freymann, D. M., Keenan, R. J., Stroud, R. M., and Walter, P. (1999)
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP,
Nat Struct Biol 6, 793-801

Nakamura, K., Yahagi, S., Yamazaki, T., and Yamane, K. (1999)
Bacillus subtilis histone-like protein, HBsu, is an integral component of a SRP-like particle that can bind the Alu domain of small cytoplasmic RNA,
J Biol Chem 274, 13569-13576


Amin, P., Sy, D. A., Pilgrim, M. L., Parry, D. H., Nussaume, L., and Hoffman, N. E. (1999)
Arabidopsis mutants lacking the 43- and 54-kilodalton subunits of the chloroplast signal recognition particle have distinct phenotypes [In Process Citation],
Plant Physiol 121, 61-70


Moll, R., Schmidtke, S., and Schafer, G. (1999)
Domain structure, GTP-hydrolyzing activity and 7S RNA binding of Acidianus ambivalens ffh-homologous protein suggest an SRP-like complex in archaea,
Eur J Biochem 259, 441-448

Clemons, W. M., Jr., Gowda, K., Black, S. D., Zwieb, C., and Ramakrishnan, V. (1999)
Crystal Structure of the Conserved Subdomain of Human Protein SRP54M at 2.1 Å Resolution: Evidence for the Mechanism of Signal Peptide Binding,
J Mol Biol 292, 697-705


Sinha, K., Perumal, K., Chen, Y., and Reddy, R. (1999)
Post-transcriptional adenylation of signal recognition particle RNA is carried out by an enzyme different from mRNA Poly(A) polymerase [In Process Citation],
J Biol Chem 274, 30826-30831


Newitt, J. A., Ulbrandt, N. D., and Bernstein, H. D. (1999)
The structure of multiple polypeptide domains determines the signal recognition particle targeting requirement of Escherichia coli inner membrane proteins,
J Bacteriol 181, 4561-4567

Stirling, C. J. (1999)
Protein targeting to the endoplasmic reticulum in yeast. 1997 Fleming Lecture,
Microbiology 145, 991-998


Cristobal, S., Scotti, P., Luirink, J., von Heijne, G., and de Gier, J. W. (1999)
The signal recognition particle-targeting pathway does not necessarily deliver proteins to the sec-translocase in Escherichia coli,
J Biol Chem 274, 20068-20070

Dalbey, R. E., and Robinson, C. (1999)
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane,
Trends Biochem Sci 24, 17-22


Strub, K., Fornallaz, M., and Bui, N. (1999)
The Alu domain homolog of the yeast signal recognition particle consists of an Srp14p homodimer and a yeast-specific RNA structure,
RNA 5, 1333-1347


Tu, C. J., Schuenemann, D., and Hoffman, N. E. (1999)
Chloroplast FtsY, chloroplast signal recognition particle, and GTP are required to reconstitute the soluble phase of light-harvesting chlorophyll protein transport into thylakoid membranes,
J Biol Chem 274, 27219-27224

Nielsen, H., Brunak, S., and von Heijne, G. (1999)
Machine learning approaches for the prediction of signal peptides and other protein sorting signals,
Protein Eng 12, 3-9.

Marley, J. J., Phenix, K. V., Irwin, C. R., Thompson, J., Robinson, P. A., and Linden, G. J. (1999)
Signal recognition particle receptor (SRPR) is downregulated in a rat model of cyclosporin A-induced gingival overgrowth,
J Periodontal Res 34, 188-196


Gowda, K., Clemons, W. M., Jr., Zwieb, C., and Black, S. D. (1999)
Expression, purification, and crystallography of the conserved methionine-rich domain of human signal recognition particle 54 kDa protein,
Protein Sci 8, 1144-1151

Wild, K., Weichenrieder, O., Leonard, G. A., and Cusack, S. (1999)
The 2 A structure of helix 6 of the human signal recognition particle RNA,
Structure Fold Des 7, 1345-1352.

Arvidson, C. G., Powers, T., Walter, P., and So, M. (1999)
Neisseria gonorrhoeae PilA is an FtsY homolog,
J Bacteriol 181, 731-739

Blatch, G. L., and Lassle, M. (1999)
The tetratricopeptide repeat: a structural motif mediating protein-protein interactions,
Bioessays 21, 932-939


Boisrame, A., Beckerich, J. M., and Gaillardin, C. (1999)
A mutation in the secretion pathway of the yeast Yarrowia lipolytica that displays synthetic lethality in combination with a mutation affecting the signal recognition particle,
Mol Gen Genet 261, 601-609


Brinkmann, H., and Philippe, H. (1999)
Archaea sister group of Bacteria? Indications from tree reconstruction artifacts in ancient phylogenies,
Mol Biol Evol 16, 817-825


Samuelsson, T., and Zwieb, N. (1999)
The Signal Recognition Particle Database (SRPDB),
Nucleic Acids Research 27, 169-170


Bui, N., and Strub, K. (1999)
New insights into signal recognition and elongation arrest activities of the signal recognition particle,
Biol Chem 380, 135-145


Schmitz, U., Behrens, S., Freymann, D. M., Keenan, R. J., Lukavsky, P., Walter, P., and James, T. L. (1999)
Structure of the phylogenetically most conserved domain of SRP RNA,
RNA 5, 1419-1429

Schmitz, U., James, T. L., Lukavsky, P., and Walter, P. (1999)
Structure of the most conserved internal loop in SRP RNA,
Nat Struct Biol 6, 634-638.

Scotti, P. A., Valent, Q. A., Manting, E. H., Urbanus, M. L., Driessen, A. J., Oudega, B., and Luirink, J. (1999)
SecA is not required for signal recognition particle-mediated targeting and initial membrane insertion of a nascent inner membrane protein,
J Biol Chem 274, 29883-29888

Valent, Q. A., Scotti, P. A., High, S., de Gier, J. W., von Heijne, G., Lentzen, G., Wintermeyer, W., Oudega, B., and Luirink, J. (1998)
The Escherichia coli SRP and SecB targeting pathways converge at the translocon,
Embo J 17, 2504-212.

von Heijne, G. (1998)
Life and death of a signal peptide,
Nature 396, 111, 113

Larsen, N., Samuelsson, T., and Zwieb, N. (1998)
The Signal Recognition Particle Database (SRPDB),
Nucleic Acids Research 26, 179-180


Gowda, K., Black, S. D., Moeller, I., Sakakibara, Y., Liu, M.-C., and Zwieb, C. (1998)
Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites,
Gene 207, 197-207


Gribaldo, S., and Cammarano, P. (1998)
The root of the universal tree of life inferred from anciently duplicated genes encoding components of the protein-targeting machinery,
J Mol Evol 47, 508-516


Plath, K., Mothes, W., Wilkinson, B. M., Stirling, C. J., and Rapoport, T. A. (1998)
Signal sequence recognition in posttranslational protein transport across the yeast ER membrane,
Cell 94, 795-807

Matoba, S., and Ogrydziak, D. M. (1998)
Another factor besides hydrophobicity can affect signal peptide interaction with signal recognition particle,
J Biol Chem 273, 18841-18847

Beckerich, J. M., Boisrame-Baudevin, A., and Gaillardin, C. (1998)
Yarrowia lipolytica: a model organism for protein secretion studies,
Int Microbiol 1, 123-130


Jacobson, M. R., and Pederson, T. (1998)
Localization of signal recognition particle RNA in the nucleolus of mammalian cells,
Proc Natl Acad Sci U S A 95, 7981-7986

Keenan, R. J., Freymann, D. M., Walter, P., and Stroud, R. M. (1998)
Crystal structure of the signal sequence binding subunit of the signal recognition particle,
Cell 94, 181-191

Schuenemann, D., Gupta, S., Persello-Cartieaux, F., Klimyuk, V. V., Jones, J. D. G., Nussaume, L., and Hoffman, N. E. (1998)
A novel signal recognition particle targets light-harvesting proteins to the thylakoid membranes,
Proc Natl Acad Sci U S A 95, 10312-10316

Chen, Y., Sinha, K., Perumal, K., Gu, J., and Reddy, R. (1998)
Accurate 3' end processing and adenylation of human signal recognition particle RNA and alu RNA in vitro,
J Biol Chem 273, 35023-35031

Ulbrandt, N. D., Newitt, J. A., and Bernstein, H. D. (1997)
The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins,
Cell 88, 187-196

Millman, J. S., and Andrews, D. W. (1997)
Switching the model: a concerted mechanism for GTPases in protein targeting,
Cell 89, 673-676

Freymann, D. M., Keenan, R. J., Stroud, R. M., and Walter, P. (1997)
Structure of the conserved GTPase domain of the signal recognition particle,
Nature 385, 361-364


Weichenrieder, O., Kapp, U., Cusack, S., and Strub, K. (1997)
Identification of a minimal Alu RNA folding domain that specifically binds SRP9/14,
RNA 3, 1262-174.

Moll, R., Schmidtke, S., Petersen, A., and Schafer, G. (1997)
The signal recognition particle receptor alpha subunit of the hyperthermophilic archaeon Acidianus ambivalens exhibits an intrinsic GTP-hydrolyzing activity,
Biochim Biophys Acta 1335, 218-230


Gowda, K., and Zwieb, C. (1997)
Determinants of a protein-induced RNA switch in the large domain of signal recognition particle identified by systematic site-directed mutagenesis,
Nucleic Acids Research 25, 2835-2840


Wilkinson, B. M., Regnacq, M., and Stirling, C. J. (1997)
Protein translocation across the membrane of the endoplasmic reticulum,
Journal of Membrane Biology 155, 189-197


Winzeler, E., Wheeler, R., and Shapiro, L. (1997)
Transcriptional analysis of the Caulobacter 4.5 S RNA ffs gene and the physiological basis of an ffs mutant with a Ts phenotype,
J Mol Biol 272, 665-676

Gowda, K., Chittenden, K., and Zwieb, C. (1997)
Binding site of the M-domain of human protein SRP 54 determined by systematic site directed mutagenesis of signal recognition particle RNA,
Nucleic Acids Research 25, 388-394


Montoya, G., Svennssom, C., Luirink, J., and Sinning, I. (1997)
Crystal structure of the NG domain from the signal-recognition particle receptor FtsY,
Nature 385, 365-368


Zelazny, A., Seluanov, A., Cooper, A., and Bibi, E. (1997)
The NG domain of the prokaryotic signal recognition particle receptor, FtsY, is fully functional when fused to an unrelated integral membrane polypeptide,
Proc Natl Acad Sci U S A 94, 6025-6029


Zheng, N., and Gierasch, L. M. (1997)
Domain interactions in E. coli SRP: stabilization of M domain by RNA is required for effective signal sequence modulation of NG domain,
Mol Cell 1, 79-87


Henry, K. A., Zwieb, C., and Fried, H. M. (1997)
Purification and biochemical characterization of the 19-kDa Signal Recognition Particle RNA-binding protein expressed as a hexahistidine-tagged polypeptide in Escherichia coli,
Protein Expression and Purification 9, 15-26


Zwieb, C., Gowda, K., Larsen, N. and Müller, F. (1997) Comparative modeling of the three-dimensional structure of signal recognition particle RNA ACS Symposium Series, in 682 (Leontis, N. B. S. L., J. Jr, Ed.) pp 405-413, American Chemical Society, Washington, DC.
Moser, C., Mol, O., Goody, R. S., and Sinning, I. (1997)
The signal recognition particle receptor of Escherichia coli (FtsY) has a nucleotide exchange factor built into the GTPase domain,
Proc Natl Acad Sci U S A 94, 11339-1144.

Lai, C., and Langley, C. H. (1997)
A homologue of the 19 kDa signal recognition particle protein locus in Drosophila melanogaster,
Gene 203, 59-63

Nielsen, H., Engelbrecht, J., Brunak, S., and von Heijne, G. (1997)
A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites,
Int J Neural Syst 8, 581-99.

Pohlschroder, M., Prinz, W. A., Hartmann, E., and Beckwith, J. (1997)
Protein translocation in the three domains of life: variations on a theme,
Cell 91, 563-56.

Chittenden, K., Gowda, K., Black, S. D., and Zwieb, C. (1997)
Interaction of rice and human SRP19 polypeptides with signal recognition particle RNA,
Plant Mol Biol 34, 507-515


Beckmann, R., Bubeck, D., Grassucci, R., Penczek, P., Verschoor, A., Blobel, G., and Frank, J. (1997)
Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex,
Science 278, 2123-2126

Ben-Shlomo, H., Levitan, A., Beja, O., and Michaeli, S. (1997)
The trypanosomatid Leptomonas collosoma 7SL RNA gene. Analysis of elements controlling its expression,
Nucleic Acids Res 25, 4977-4984


Birse, D. E., Kapp, U., Strub, K., Cusack, S., and Aberg, A. (1997)
The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14,
Embo J 16, 3757-3766


Black, S. D., Gowda, K., Chittenden, K., Walker, K. P., 3rd, and Zwieb, C. (1997)
Identification of an RNA-binding-loop in the N-terminal region of signal-recognition-particle protein SRP19,
Eur J Biochem 245, 564-572

Ronimus, R. S., and Musgrave, D. R. (1997)
Identification of a gene in the euryarchaeal Thermococcus species AN1 encoding a protein homologous to the alpha subunit of the eukaryal signal recognition particle (SRP) receptor,
Biochim Biophys Acta 1351, 1-8


Chang, D. Y., Newitt, J. A., Hsu, K., Bernstein, H. D., and Maraia, R. J. (1997)
A highly conserved nucleotide in the Alu domain of SRP RNA mediates translation arrest through high affinity binding to SRP9/14,
Nucleic Acids Res 25, 1117-1122


Nielsen, H., Engelbrecht, J., Brunak, S., and von Heijne, G. (1997)
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites,
Protein Eng 10, 1-6.

Moll, R., Schmidtke, S., and Schaefer, G. (1996)
A putative signal recognition particle receptor alpha subunit (SR alpha) homologue is expressed in the hyperthermophilic crenarchaeon Sulfolobus acidocaldarius,
FEMS Microbiol Lett 137, 51-56


Ng, D. T., Brown, J. D., and Walter, P. (1996)
Signal sequences specify the targeting route to the endoplasmic reticulum membrane,
Journal of Cell Biology 134, 269-278


Andrews, D. W., and Johnson, A. E. (1996)
The translocon: more than a hole in the ER membrane?,
Trends Biochem Sci 21, 365-369

Nielsen, H., Engelbrecht, J., von Heijne, G., and Brunak, S. (1996)
Defining a similarity threshold for a functional protein sequence pattern: the signal peptide cleavage site,
Proteins 24, 165-77.

Bacher, G., Lutcke, H., Jungnickel, B., Rapoport, T. A., and Dobberstein, B. (1996)
Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting,
Nature 381, 248-251

Packer, J. C., and Howe, C. J. (1996)
The cyanobacterial genome contains a single copy of the ffh gene encoding a homologue of the 54 kDa subunit of signal recognition particle,
Plant Molecular Biology 30, 659-665


Patel, S., and Austen, B. M. (1996)
Substitution of fifty four homologue (Ffh) in Escherichia coli with the mammalian 54-kDa protein of signal-recognition particle,
European Journal of Biochemistry 238, 760-768


Belin, D., Bost, S., Vassalli, J. D., and Strub, K. (1996)
A two-step recognition of signal sequences determines the translocation efficiency of proteins,
EMBO Journal 15, 468-478


Powers, T., and Walter, P. (1996)
Protein targeting. The ribosome talks back [news; comment],
Nature 381, 191-192


Birse, D. E., Doublie, S., Kapp, U., Strub, K., Cusack, S., and Aberg, A. (1996)
Crystallization and preliminary crystallographic analysis of the signal recognition particle SRPphi14-9 fusion protein,
FEBS Letters 384, 215-218


Riedel, L., Volger, U., Luckinger, R., Putz, A., Sanger, H. L., and Wassenegger, M. (1996)
Molecular analysis of the gene family of the signal recognition particle (SRP) RNA of tomato,
Plant Molecular Biology 31, 113-125


Schmitz, U., Freymann, D. M., James, T. L., Keenan, R. J., Vinayak, R., and Walter, P. (1996)
NMR studies of the most conserved RNA domain of the mammalian signal recognition particle (SRP),
RNA 2, 1213-127.

Shibata, T., Fujii, Y., Nakamura, Y., Nakamura, K., and Yamane, K. (1996)
Identification of protein synthesis elongation factor G as a 4.5 S RNA-binding protein in Escherichia coli,
Journal of Biological Chemistry 271, 13162-13168


de Gier, J. W., Mansournia, P., Valent, Q. A., Phillips, G. J., Luirink, J., and von Heijne, G. (1996)
Assembly of a cytoplasmic membrane protein in Escherichia coli is dependent on the signal recognition particle,
FEBS Lett 399, 307-309

Larsen, N., and Zwieb, C. (1996)
The signal recognition particle database (SRPDB),
Nucleic acids research 24, 80-81


Lentzen, G., Moine, H., Ehresmann, C., Ehresmann, B., and Wintermeyer, W. (1996)
Structure of 4.5S RNA in the signal recognition particle of Escherichia coli as studied by enzymatic and chemical probing,
RNA 2, 244-253

Levine, R. L., Mosoni, L., Berlett, B., and Stadtman, E. R. (1996)
Methionine residues as endogenous antioxidants in proteins,
Procedings of the National Academy of Sciences U.S.A. 93, 15036-15040


Voigt, S., Jungnickel, B., Hartmann, E., and Rapoport, T. A. (1996)
Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane,
Journal of Cell Biology 134, 25-35


Doublie, S., Kapp, U., Aberg, A., Brown, K., Strub, K., and Cusack, S. (1996)
Crystallization and preliminary X-ray analysis of the 9 kDa protein of the mouse signal recognition particle and the selenomethionyl-SRP9,
FEBS Letters 384, 219-221


Young, J. C., and Andrews, D. W. (1996)
The signal recognition particle receptor alpha subunit assembles co-translationally on the endoplasmic reticulum membrane during an mRNA-encoded translation pause in vitro,
EMBO Journal 15, 172-181


Zheng, N., and Gierasch, L. M. (1996)
Signal sequences: the same yet different,
Cell 86, 849-852

Zwieb, C., Müller, F., and Larsen, N. (1996)
Comparative analysis of tertiary structure elements in signal recognition particle RNA,
Folding & Design 1, 315-324


Kurita, K., Honda, K., Suzuma, S., Takamatsu, H., Nakamura, K., and Yamane, K. (1996)
Identification of a region of Bacillus subtilis Ffh, a homologue of mammalian SRP54 protein, that is essential for binding to small cytoplasmic RNA,
Journal of Biological Chemistry 271, 13140-13146


Miller, J. D., Tajima, S., Lauffer, L., and Walter, P. (1995)
The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane,
Journal of Cell Biology 128, 273-282


Walker, P. K., Black, S. D., and Zwieb, C. (1995)
Cooperative assembly of signal recognition particle RNA with protein SRP19,
Biochemistry 34, 11989-11997


Watson, B. S., Hazlett, T. L., Eccleston, J. F., Davis, C., Jameson, D. M., and Johnson, A. E. (1995)
Macromolecular arrangement in the aminoacyl-tRNA.elongation factor Tu.GTP ternary complex. A fluorescence energy transfer study,
Biochemistry 34, 7904-7912


Wickner, W. (1995)
The nascent-polypeptide-associated complex: having a "NAC" for fidelity in translocation [comment],
Proc Natl Acad Sci U S A 92, 9433-9434


Young, J. C., Ursini, J., Legate, K. R., Miller, J. D., Walter, P., and Andrews, D. W. (1995)
An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane,
Journal of Biological Chemistry 270, 15650-15657


Kusters, R., Lentzen, G., Eppens, E., van Geel, A., van der Weijden, C. C., Wintermeyer, W., and Luirink, J. (1995)
The functioning of the SRP receptor FtsY in protein-targeting in E. coli is correlated with its ability to bind and hydrolyse GTP,
FEBS Letters 372, 253-258


Nakamura, K., Hashizume, E., Shibata, T., Nakamura, Y., Mala, S., and Yamane, K. (1995)
Small cytoplasmic RNA (scRNA) gene from Clostridium perfringens can replace the gene for the Bacillus subtilis scRNA in both growth and sporulation,
Microbiology 141, 2965-2975


Lauring, B., Kreibich, G., and Wiedmann, M. (1995)
The intrinsic ability of ribosomes to bind to endoplasmic reticulum membranes is regulated by signal recognition particle and nascent-polypeptide-associated complex [see comments],
Proc Natl Acad Sci U S A 92, 9435-9439


Lauring, B., Sakai, H., Kreibich, G., and Wiedmann, M. (1995)
Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum [published erratum appears in Proc Natl Acad Sci U S A 1995 Aug 15;92(17):8088],
Proc Natl Acad Sci U S A 92, 5411-5415


Li, X., Henry, R., Yuan, J., Cline, K., and Hoffman, N. E. (1995)
A chloroplast homologue of the signal recognition particle subunit SRP54 is involved in the posttranslational integration of a protein into thylakoid membranes,
Proceedings of the National Academy of Sciences of U.S.A 92, 3789-3793


Lyko, F., Martoglio, B., Jungnickel, B., Rapoport, T. A., and Dobberstein, B. (1995)
Signal sequence processing in rough microsomes,
Journal of Biological Chemistry 270, 19873-19878


Lütcke, H. (1995)
Signal recognition particle (SRP), a ubiquitous initiator of protein translocation,
Eur J Biochem 228, 531-550

Macfarlane, J., and Muller, M. (1995)
The functional integration of a polytopic membrane protein of Escherichia coli is dependent on the bacterial signal-recognition particle,
European Journal of Biochemistry 233, 766-771


McNair, A., Zemzoumi, K., Lutcke, H., Guillerm, C., Boitelle, A., Capron, A., and Dissous, C. (1995)
Cloning of a signal-recognition-particle subunit of Schistosoma mansoni,
Parasitology Research 81, 175-177


Ogg, S. C., and Walter, P. (1995)
SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation,
Cell 81, 1075-1084


Persson, B. C., Bylund, G. O., Berg, D. E., and Wikstrom, P. M. (1995)
Functional analysis of the ffh-trmD region of the Escherichia coli chromosome by using reverse genetics,
J Bacteriol 177, 5554-5560


Powers, T., and Walter, P. (1995)
Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases,
Science 269, 1422-1424


Riedel, L., Putz, A., Hauser, M. T., Luckinger, R., Wassenegger, M., and Sanger, H. L. (1995)
Characterization of the signal recognition particle (SRP) RNA population of tomato (Lycopersicon esculentum),
Plant Mol Biol 27, 669-680

Samuelsson, T., Olsson, M., Wikstrom, P. M., and Johansson, B. R. (1995)
The GTPase activity of the Escherichia coli Ffh protein is important for normal growth,
Biochimica et Biophysica Acta 1267, 83-91


Brown, J. D., Hann, B. C., Medzihradszky, K. F., Niwa, M., Burlingame, A. L., and Walter, P. (1994)
Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression,
EMBO J 13, 4390-4400


Chittenden, K., Black, S. D., and Zwieb, C. (1994)
Systematic site-directed mutagenesis of protein SRP19: identification of the residues essential for binding to signal recognition particle RNA,
Journal of Biological Chemistry 269, 20497-20502


Choquet, C. G., Patel, G. B., Beveridge, T. J., and Sprott, G. D. (1994)
Stability of pressure-extruded liposomes made from archaeobacterial ether lipids,
Appl Microbiol Biotechnol 42, 375-84.

Chu, B., Lindstrom, J. T., and Belanger, F. C. (1994)
Arabidopsis thaliana expresses three divergent Srp54 genes,
Plant Physiol 106, 1157-1162


Crowley, K. S., Liao, S., Worrell, V. E., Reinhart, G. D., and Johnson, A. E. (1994)
Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore,
Cell 78, 461-471


Czarnota, G. J., Andrews, D. W., Farrow, N. A., and Ottensmeyer, F. P. (1994)
A structure for the signal sequence binding protein SRP54: 3D reconstruction from STEM images of single molecules,
Journal of Structural Biology 113, 35-46


Dobberstein, B. (1994)
Protein transport. On the beaten pathway [news; comment],
Nature 367, 599-600


Althoff, S. M., Stevens, S. W., and Wise, J. A. (1994)
The SRP54 GTPase is essential for protein export in the fission yeast Schizosaccharomyces pombe,
Molecular & Cellular Biology 14, 7839-7854


Althoff, S., Selinger, D., and Wise, J. A. (1994)
Molecular evolution of SRP cycle components: functional implications,
Nucleic Acids Res 22, 1933-1947

He, X. P., Bataille, N., and Fried, H. M. (1994)
Nuclear export of signal recognition particle RNA is a facilitated process that involves the Alu sequence domain,
Journal of Cell Science 107, 903-912


Jensen, C. G., and Pedersen, S. (1994)
Concentrations of 4.5S RNA and Ffh protein in Escherichia coli: the stability of Ffh protein is dependent on the concentration of 4.5S RNA,
Journal of Bacteriology 176, 7148-7154


Jensen, C. G., Brown, S., and Pedersen, S. (1994)
Effect of 4.5S RNA depletion on Escherichia coli protein synthesis and secretion,
Journal of Bacteriology 176, 2502-2506


Jones, J. D., and Gierasch, L. M. (1994)
Effect of charged residue substitutions on the membrane-interactive properties of signal sequences of the Escherichia coli LamB protein,
Biophys J 67, 1534-1545


Jung, C., and Zimmermann, R. (1994)
The relationship between size of a presecretory protein and extent of signal-recognition-particle-mediated arrest of its translation,
Biochemical & Biophysical Research Communications 205, 603-611


Lentzen, G., Dobberstein, B., and Wintermeyer, W. (1994)
Formation of SRP-like particles induces a conformational change in E.coli 4.5S RNA,
FEBS Letters 348, 233-238


Luirink, J., and Dobberstein, B. (1994)
Mammalian and Escherichia coli signal recognition particles. [Review],
Molecular Microbiology 11, 9-13


Luirink, J., ten Hagen-Jongman, C. M., van der Weijden, C. C., Oudega, B., High, S., Dobberstein, B., and Kusters, R. (1994)
An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY,
EMBO Journal 13, 2289-2296


Miller, J. D., Bernstein, H. D., and Walter, P. (1994)
Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor [see comments],
Nature 367, 657-659


Walter, P., and Johnson, A. E. (1994)
Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. [Review],
Annual Review of Cell Biology 10, 87-119


Ng, D. T., and Walter, P. (1994)
Protein translocation across the endoplasmic reticulum. [Review],
Current Opinion in Cell Biology 6, 510-516


Wickner, W. T. (1994)
How ATP drives proteins across membranes [comment],
Science 266, 1197-1198


Wiedmann, B., Sakai, H., Davis, T. A., and Wiedmann, M. (1994)
A protein complex required for signal-sequence-specific sorting and translocation,
Nature 370, 434-440


Wolin, S. L. (1994)
From the elephant to E. coli: SRP-dependent protein targeting. [Review],
Cell 77, 787-790


Zwieb, C. (1994)
Site-directed mutagenesis of signal recognition particle RNA: identification of the nucleotides in helix 8 required for interaction with protein SRP19,
European Journal of Biochemistry 222, 885-890


Nishiguchi, M., Honda, K., Amikura, R., Nakamura, K., and Yamane, K. (1994)
Structural requirements of Bacillus subtilis small cytoplasmic RNA for cell growth, sporulation, and extracellular enzyme production,
Journal of Bacteriology 176, 157-165


Zwieb, C., and Larsen, N. (1994)
The signal recognition particle database (SRPDB),
Nucleic acids research 22, 3483-3487


Nakamura, K., Nishiguchi, M., Honda, K., and Yamane, K. (1994)
The Bacillus subtilis SRP54 homologue, Ffh, has an intrinsic GTPase activity and forms a ribonucleoprotein complex with small cytoplasmic RNA in vivo,
Biochemical & Biophysical Research Communications 199, 1394-1399


Nakamura, K., Nishiguchi, M., Minemura, M., Honda, K., and Yamane, K. (1994)
Small cytoplasmic RNA of Bacillus brevis: transcriptional and phylogenetic analysis,
Microbiology 140, 493-498


Patel, S., and Austen, B. (1994)
The structure of the signal-binding domain of the 54 kDa subunit of signal recognition particle and its role in membrane insertion,
Biochemical Society Transactions 22, 1030-1033


Quentin, Y. (1994)
Emergence of master sequences in families of retroposons derived from 7sl RNA. [Review],
Genetica 93, 203-215


Rapiejko, P. J., and Gilmore, R. (1994)
Signal sequence recognition and targeting of ribosomes to the endoplasmic reticulum by the signal recognition particle do not require GTP,
Molecular Biology of the Cell 5, 887-897


Schlenstedt, G., Zimmermann, M., and Zimmermann, R. (1994)
A stably folded presecretory protein associates with and upon unfolding translocates across the membrane of mammalian microsomes,
FEBS Letters 340, 139-144


Selinger, D., Brennwald, P., althoff, S., Reich, C., Hann, B., Walter, P., and Wise, J. A. (1994)
Genetic and biochemical analysis of the fission yeast
ribonucleoprotein particle containing a homolog of Srp54p,
Nucleic Acids Research 22, 2557-2567


Lindstrom, J. T., Chu, B., and Belanger, F. C. (1993)
Isolation and characterization of an Arabidopsis thaliana gene for the 54 kDa subunit of the signal recognition particle,
Plant Molecular Biology 23, 1265-1272


Wolin, S. L., and Walter, P. (1993)
Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes,
Journal of Cell Biology 121, 1211-1219


Zopf, D., Bernstein, H. D., and Walter, P. (1993)
GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding,
Journal of Cell Biology 120, 1113-1121


Honda, K., Nakamura, K., Nishiguchi, M., and Yamane, K. (1993)
Cloning and characterization of a Bacillus subtilis gene encoding a homolog of the 54-kilodalton subunit of mammalian signal recognition particle and Escherichia coli Ffh,
Journal of Bacteriology 175, 4885-4894


Johnson, A. E. (1993)
Protein translocation across the ER membrane: a fluorescent light at the end of the tunnel. [Review],
Trends in Biochemical Sciences 18, 456-458


Larsen, N., and Zwieb, C. (1993)
The signal recognition particle database (SRPDB),
Nucleic Acids Res 21, 3019-3020


Lütcke, H., Prehn, S., Ashford, A. J., Remus, M., Frank, R., and Dobberstein, B. (1993)
Assembly of the 68- and 72-kD proteins of signal recognition particle with 7S RNA,
J Cell Biol 121, 977-985


Miller, J. D., and Walter, P. (1993)
A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane. [Review],
Ciba Foundation Symposium 176, 147-59; discussion 159-63


Miller, J. D., Wilhelm, H., Gierasch, L., Gilmore, R., and Walter, P. (1993)
GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation,
Nature 366, 351-354


Bernstein, H. D., Zopf, D., Freymann, D. M., and Walter, P. (1993)
Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog,
Proc Natl Acad Sci U S A 90, 5229-5233


Rizo, J., Blanco, F. J., Kobe, B., Bruch, M. D., and Gierasch, L. M. (1993)
Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments,
Biochemistry 32, 4881-4894


Robinson, A., He, M., Westwood, O. M., and Austen, B. M. (1993)
Changes in levels of pancreatic endoplasmic reticulum proteins that function in translocation and maturation of secretory proteins in response to cholecystokinin,
Cytotechnology 11, 197-204


Selinger, D., Brennwald, P., Liao, X., and Wise, J. A. (1993)
Identification of RNA sequences and structural elements required for assembly of fission yeast SRP54 protein with signal recognition particle RNA,
Molecular & Cellular Biology 13, 1353-1362


Selinger, D., Liao, X., and Wise, J. A. (1993)
Functional interchangeability of the structurally similar tetranucleotide loops GAAA and UUCG in fission yeast signal recognition particle RNA,
Proceedings of the National Academy of Sciences of the United States of America 90, 5409-5413


Shelness, G. S., Lin, L., and Nicchitta, C. V. (1993)
Membrane topology and biogenesis of eukaryotic signal peptidase,
Journal of Biological Chemistry 268, 5201-5208


Connolly, T., and Gilmore, R. (1993)
GTP hydrolysis by complexes of the signal recognition particle and the signal recognition particle receptor,
Journal of Cell Biology 123, 799-807


Dierks, T., Klappa, P., Wiech, H., and Zimmermann, R. (1993)
The role of molecular chaperones in protein transport into the endoplasmic reticulum. [Review],
Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences 339, 335-341


Doud, S. K., Chou, M. M., and Kendall, D. A. (1993)
Titration of protein transport activity by incremental changes in signal peptide hydrophobicity,
Biochemistry 32, 1251-1256


Hann, B. C., Stirling, C. J., and Walter, P. (1992)
SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity,
Nature 356, 532-533


He, F., Beckerich, J. M., and Gaillardin, C. (1992)
A mutant of 7SL RNA in Yarrowia lipolytica affecting the synthesis of a secreted protein,
Journal of Biological Chemistry 267, 1932-1937


Zwieb, C. (1992)
Conformity of RNAs that interact with tetranucleotide loop binding proteins,
Nucleic acids research 20, 4397-4400


Wood, H., Luirink, J., and Tollervey, D. (1992)
Evolutionary conserved nucleotides within the E. coli 4.5S RNA are required for association with P48 in vitro and for optimal function in vivo,
Nucleic Acids Research 20, 5919-5925


Zwieb, C. (1992)
Recognition of a tetranucleotide loop of signal recognition particle RNA by protein SRP19,
J. Biol. Chem. 267, 15650-15656


Yaver, D. S., Matoba, S., and Ogrydziak, D. M. (1992)
A mutation in the signal recognition particle 7S RNA of the yeast Yarrowia lipolytica preferentially affects synthesis of the alkaline extracellular protease: in vivo evidence for translational arrest,
Journal of Cell Biology 116, 605-616


Gropp, R., Gropp, F., and Betlach, M. C. (1992)
Association of the halobacterial 7S RNA to the polysome correlates with expression of the membrane protein bacterioopsin,
Proceedings of the National Academy of Sciences of the United States of America 89, 1204-1208


Görlich, D., Hartmann, E., Prehn, S., and Rapoport, T. A. (1992)
A protein of the endoplasmic reticulum involved early in polypeptide translocation,
Nature 357, 47-52


Zwieb, C., and Larsen, N. (1992)
The signal recognition particle (SRP) database,
Nucleic acids research 20, Supplement, 2207


High, S., and Dobberstein, B. (1992)
Mechanisms that determine the transmembrane disposition of proteins,
Curr Opin Cell Biol 4, 581-586


Janiak, F., Walter, P., and Johnson, A. E. (1992)
Fluorescence-detected assembly of the signal recognition particle: binding of the two SRP protein heterodimers to SRP RNA is noncooperative,
Biochemistry 31, 5830-5840


Janin, N., Delattre, O., and Lipinski, M. (1992)
PCR-assisted localization of the human SRPR gene,
Human Genetics 88, 583-585


Mitoma, J., and Ito, A. (1992)
The carboxy-terminal 10 amino acid residues of cytochrome b5 are necessary for its targeting to the endoplasmic reticulum,
EMBO Journal 11, 4197-4203


Andersson, H., Bakker, E., and von Heijne, G. (1992)
Different positively charged amino acids have similar effects on the topology of a polytopic transmembrane protein in Escherichia coli,
J Biol Chem 267, 1491-1495


Liao, X., Selinger, D., althoff, S., Chiang, A., Hamilton, D., Ma, M., and Wise, J. A. (1992)
Random mutagenesis of Schizosaccharomyces pombe SRP RNA: lethal and conditional lesions cluster in presumptive protein binding sites,
Nucleic Acids Research 20, 1607-1615


Luirink, J., High, S., Wood, H., Giner, A., and others, a. (1992)
Signal-sequence recognition by an Escherichia coli ribonucleoprotein complex,
Nature 359, 741-743


Lütcke, H., High, S., Römisch, K., Ashford, A. J., and Dobberstein, B. (1992)
The methionine-rich domain of the 54 kDa subunit of signal recognition particle is sufficient for the interaction with signal sequences,
EMBO Journal 11, 1543-1551


Michaeli, S., Podell, D., Agabian, N., and Ullu, E. (1992)
The 7SL RNA homologue of Trypanosoma brucei is closely related to mammalian 7SL RNA,
Molecular & Biochemical Parasitology 51, 55-64


Migliaccio, G., Nicchitta, C. V., and Blobel, G. (1992)
The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation,
Journal of Cell Biology 117, 15-25


Nunnari, J., and Walter, P. (1992)
Protein targeting to and translocation across the membrane of the endoplasmic reticulum,
Current Opinion in Cell Biology 4, 573-580


Ogg, S. C., Poritz, M. A., and Walter, P. (1992)
Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae,
Molecular Biology of the Cell 3, 895-911


Okun, M. M., and Shields, D. (1992)
Translocation of preproinsulin across the endoplasmic reticulum membrane. The relationship between nascent polypeptide size and extent of signal recognition particle-mediated inhibition of protein synthesis,
Journal of Biological Chemistry 267, 11476-11482


Olender, E. H., and Simon, R. D. (1992)
The intracellular targeting and membrane topology of 3-hydroxy-3-methylglutaryl-CoA reductase,
Journal of Biological Chemistry 267, 4223-4235


Phillips, G. J., and Silhavy, T. J. (1992)
The E. coli ffh gene is necessary for viability and efficient protein export,
Nature (London) 359, 744-746


Rapiejko, P. J., and Gilmore, R. (1992)
Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor,
Journal of Cell Biology 117, 493-503


Sakaguchi, M., Tomiyoshi, R., Kuroiwa, T., Mihara, K., and Omura, T. (1992)
Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge,
Proceedings of the National Academy of Sciences of the United States of America 89, 16-19


Schlenstedt, G., Gudmundsson, G. H., Boman, H. G., and Zimmermann, R. (1992)
Structural requirements for transport of preprocecropinA and related presecretory proteins into mammalian microsomes,
Journal of Biological Chemistry 267, 24328-24332


Stirling, C. J., and Hewitt, E. W. (1992)
The S. cerevisiae SEC65 gene encodes a components of yeast signal recognition particle with homology to human SRP19,
Nature (London) 356, 534-537


Andreazzoli, M., and Gerbi, S. A. (1991)
Changes in 7SL RNA conformation during the signal recognition particle cycle,
Embo J 10, 767-777


Lingappa, V. R. (1991)
The role of the endoplasmic reticulum in nascent chain translocation: a perspective from the study of chimeric proteins,
Intracellular trafficking of proteins 387-430


Larsen, N., and Zwieb, C. (1991)
SRP-RNA sequence alignment and secondary structure,
Nucleic Acids Res 19, 209-215


Zimmermann, R., Zimmermann, M., Mayinger, P., and Klappa, P. (1991)
Photoaffinity labeling of dog pancreas microsomes with 8-azido-ATP inhibits association of nascent preprolactin with the signal sequence receptor complex,
Febs Lett 286, 95-99


Görlich, D., Kurzchalia, T. V., Wiedmann, M., and Rapoport, T. A. (1991)
Probing the molecular environment of translocating polypeptide chains by cross-linking,
Meth. Cell Biol. 34, 241-262


Hann, B. C., and Walter, P. (1991)
The signal recognition particle in S. cerevisiae,
Cell 67, 131-144


Amaya, Y., and Nakano, A. (1991)
SRH1 protein, the yeast homologue of the 54 kDa subunit of signal recognition particle, is involved in ER translocation of secretory proteins,
Febs Lett 283, 325-328


Nunnari, J. M., Zimmerman, D. L., Ogg, S. C., and Walter, P. (1991)
Characterization of the rough endoplasmic reticulum ribosome-binding activity,
Nature 352, 638-640


Heus, H. A., and Pardi, A. (1991)
Structural features that give rise to the unusual stability of RNA hairpins containing GNRA loops,
Science 253, 191-194


High, S., and Dobberstein, B. (1991)
The signal sequence interacts with the methionine-rich domain of the 54-kD protein of signal recognition particle,
Journal of Cell Biology 113, 229-233


Zwieb, C. (1991)
Interaction of protein SRP19 with signal recognition particle RNA lacking individual RNA-helices,
Nucleic Acids Res 19, 2955-2960

Hoyt, D. W., and Gierasch, L. M. (1991)
A peptide corresponding to an export-defective mutant OmpA signal sequence with asparagine in the hydrophobic core is unable to insert into model membranes,
J Biol Chem 266, 14406-14412


Brown, S. (1991)
Genes for 7S RNAs can replace the gene for 4.5S RNA in growth of Escherichia coli,
J Bacteriol 173, 1835-1837


Zwieb, C. (1991)
A basic region neighboring the lysine-rich C-terminus of protein SRP19 is required for binding to signal recognition particle RNA,
Biochem Cell Biol 69, 649-654

Connolly, T., Rapiejko, P. J., and Gilmore, R. (1991)
Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor,
Science 252, 1171-1173


Strub, K., Moss, J., and Walter, P. (1991)
Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution,
Mol Cell Biol 11, 3949-3959


Zopf, D., Bernstein, H. D., Johnson, A. E., and Walter, P. (1990)
The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence,
EMBO J 9, 4511-4517


Görlich, D., Prehn, S., Hartmann, E., Herz, J., Otto, A., Kraft, R., Wiedmann, M., Knespel, S., Dobberstein, B., and Rapoport, T. A. (1990)
The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents,
J Cell Biol 111, 2283-2294


Herz, J., Flint, N., Stanley, K., Frank, R., and Dobberstein, B. (1990)
The 68 kDa protein of signal recognition particle contains a glycine-rich region also found in certain RNA-binding proteins,
Febs Lett 276, 103-107


Amaya, Y., Nakano, A., Ito, K., and Mori, M. (1990)
Isolation of a yeast gene, SRH1, that encodes a homologue of the 54K subunit of mammalian signal recognition particle,
J Biochem (Tokyo) 107, 457-463


Jones, J. D., McKnight, C. J., and Gierasch, L. M. (1990)
Biophysical studies of signal peptides: implications for signal sequence functions and the involvement of lipid in protein export,
J Bioenerg Biomembr 22, 213-232


Poritz, M. A., Bernstein, H. D., Strub, K., Zopf, D., Wilhelm, H., and Walter, P. (1990)
An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle,
Science 250, 1111-1117


Prehn, S., Herz, J., Hartmann, E., Kurzchalia, T. V., Frank, R., Römisch, K., Dobberstein, B., and Rapoport, T. A. (1990)
Structure and biosynthesis of the signal-sequence receptor,
Eur J Biochem 188, 439-445


Ribes, V., Römisch, K., Giner, A., Dobberstein, B., and Tollervey, D. (1990)
E. coli 4.5S RNA is part of a ribonucleoprotein particle that has properties related to signal recognition particle,
Cell 63, 591-600


Römisch, K., Webb, J., Lingelbach, K., Gausepohl, H., and Dobberstein, B. (1990)
The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain,
Journal of Cell Biology 111, 1793-1802


Strub, K., and Walter, P. (1990)
Assembly of the alu domain of signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA,
Molecular and Cell Biology 10, 777-784


von Heijne, G. (1990)
The signal peptide,
J Membr Biol 115, 195-201


Ngsee, J. K., and Smith, M. (1990)
Changes in a mammalian signal sequence required for efficient protein secretion by yeasts,
Gene 86, 251-255


LeBlanc, J. M., and Infante, A. A. (1989)
Association of 7 SL RNA and an SRP-like particle with polysomes and endoplasmic reticulum in the developing sea urchin embryo,
Dev Biol 132, 139-152

Liao, X., Brennwald, P., and Wise, J. A. (1989)
Genetic analysis of Schizosaccharmyces pombe 7SL RNA: A structural motif that includes a conserved tetranucleotide loop is important for function,
Proc. Natl. Acad. Sci. USA 86, 4137-4141


Marshallsay, C., Prehn, S., and Zwieb, C. (1989)
cDNA cloning of the wheat germ SRP 7S RNAs,
Nucleic acids research 17, 1771


Hann, B. C., Poritz, M. A., and Walter, P. (1989)
Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth,
J Cell Biol 109, 3223-3230


Gierasch, L. M. (1989)
Signal sequences [published erratum appears in Biochemistry 1989 Jun 27;28(13):5702],
Biochemistry 28, 923-930


Zwieb, C., and Schüler, D. (1989)
Low resolution three-dimensional models of the 7SL RNA of the signal recognition particle, based on an intramolecular cross-link introduced by mild irradiation with ultraviolet light,
Biochem. and Cell Biol. 67, 434-442


Bernstein, H. D., Poritz, M. A., Strub, K., Hoben, P. J., Brenner, S., and Walter, P. (1989)
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle,
Nature 340, 482-486


Bruch, M. D., McKnight, C. J., and Gierasch, L. M. (1989)
Helix formation and stability in a signal sequence,
Biochemistry 28, 8554-8561


Andrews, D. W., Lauffer, L., Walter, P., and Lingappa, V. R. (1989)
Evidence for a two-step mechanism involved in assembly of functional signal recognition particle receptor,
J Cell Biol 108, 797-810

Campos, N., Palau, J., and Zwieb, C. (1989)
Diversity of 7 SL RNA from the signal recognition particle of maize endosperm,
Nucleic Acids Res 17, 1573-1588

Connolly, T., and Gilmore, R. (1989)
The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide,
Cell 57, 599-610


Strub, K., and Walter, P. (1989)
Cross-hybridization of differently primed polymerase chain reaction: isolation of a cDNA clone for the 14-kDa subunit of the signal recognition particle by cross-hybridization of differently primed polymerase chain reactions,
Proc Natl Acad Sci U S A 86, 9747-9751


Felici, F., Cesareni, G., and Hughes, J. M. (1989)
The most abundant small cytoplasmic RNA of Saccharomyces cerevisiae has an important function required for normal cell growth,
Mol Cell Biol 9, 3260-3268


Ribes, V., Dehoux, P., and Tollervey, D. (1988)
7SL RNA from Schizosaccharomyces pombe is encoded by a single copy essential gene,
EMBO Journal 7, 231-237


Brennwald, P., Liao, X., Holm, K., Porter, G., and Wise, J. A. (1988)
Identification of an essential Schizosaccharomyces pombe RNA homologous to the 7SL component of signal recognition particle,
Mol Cell Biol 8, 1580-1590

Zwieb, C. (1988)
4.5S RNA of E. coli and the conserved central domain of signal recognition particle RNA are homologous,
Endocyt. C. Res. 5, 327-336


Garcia, P. D., and Walter, P. (1988)
Full-length prepro-alpha-factor can be translocated across the mammalian microsomal membrane only if translation has not terminated,
J Cell Biol 106, 1043-1048

Poritz, M. A., Siegel, V., Hansen, W., and Walter, P. (1988)
Small ribonucleoproteins in Schizosaccharomyces pombe and Yarrowia lipolytica homologous to signal recognition particle,
Procedings of the National Academy of Sciences U.S.A. 85, 4315-4319


Poritz, M. A., Strub, K., and Walter, P. (1988)
Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain,
Cell 55, 4-6

Lingelbach, K., Zwieb, C., Webb, J. R., Marshallsay, C., Hoben, P. J., Walter, P., and Dobberstein, B. (1988)
Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA,
Nucleic Acids Research 16, 9431-9442


Zwieb, C. (1988)
3D-modeling of the 7SL RNA of the signal recognition particle,
J. Cell. Biochem Supplement 12D, 27


Campos, N., Palau, J., Torrent, M., and Ludevid, D. (1988)
Signal recognition-like particles are present in maize,
J Biol Chem 263, 9646-9650

Siegel, V., and Walter, P. (1988)
Each of the activities of signal recognition particle (SRP) is contained with a distinct domain: analysis of biochemical mutants of SRP,
Cell 52, 39-49


Siegel, V., and Walter, P. (1988)
Binding sites of the 19-kDa and 68/72-kDa signal recognition particle (SRP) proteins on SRP RNA as determined in protein-RNA 'footprinting',
Proc Natl Acad Sci U.S.A. 85, 1801-1805


Siegel, V., and Walter, P. (1988)
The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length,
Embo J 7, 1769-1775

Andrews, D. W., Walter, P., and Ottensmeyer, F. P. (1987)
Evidence for an extended 7SL RNA structure in the signal recognition particle,
EMBO J 6, 3471-3477

Wiedmann, M., Kurzchalia, T. V., Hartman, E., and Rapoport, T. A. (1987)
A signal sequence receptor in the endoplasmic reticulum membrane,
Nature 328, 830-833


Wiedmann, M., Kurzchalia, T. V., Bielka, H., and Rapoport, T. A. (1987)
Direct probing of the interaction between the signal sequence of nascent preprolactin and the signal recognition particle by specific cross-linking,
Journal of Cell Biology 104, 201-208


Prehn, S., Wiedmann, M., Rapoport, T. A., and Zwieb, C. (1987)
Protein translocation across wheat germ microsomal membranes requires an SRP-like component,
EMBO J. 6, 2093-2097


Zwieb, C. (1987)
3D-modeling of the 7SL RNA of the signal recognition particle,
Mol. Biol. Reports 12, 221-222


Andrews, P. G., and Kole, R. (1987)
Alu RNA transcribed in vitro binds the 68-kDa subunit of the signal recognition particle,
J Biol Chem 262, 2908-2912

Scoulica, E., Krause, E., Meese, K., and Dobberstein, B. (1987)
Disassembly and domain structure of the proteins in the signal-recognition particle,
Eur J Biochem 163, 519-528

Walter, P. (1987)
Two receptors act sequentially,
Nature 328, 763-764


Lipp, J., and Dobberstein, B. (1986)
Signal recognition particle-dependent membrane insertion of mouse invariant chain: a membrane-spanning protein with a cytoplasmically exposed amino terminus,
J Cell Biol 102, 2169-2175

Krieg, U. C., Walter, P., and Johnson, A. E. (1986)
Photocrosslinking of the signal sequence of nascent preprolaction to the 54-kilodalton polypeptide of the signal recognition particle,
Procedings of the National Academy of Sciences U.S.A. 83, 8604-8608


Kurzchalia, T. V., Wiedmann, M., Girshovich, A. S., Bochkareva, E. S., Bielka, H., and Rapoport, T. A. (1986)
The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle,
Nature 320, 634-636

Hortsch, M., Avossa, D., and Meyer, D. I. (1986)
Characterization of secretory protein translocation: ribosome-membrane interaction in endoplasmic reticulum,
J Cell Biol 103, 241-253

Zwieb, C. (1986)
Is the 6S RNA of prokaryotes an equivalent to the 7SL RNA of eukaryotes?,
Endocyt. C. Res. 3, 41-51


Ibrahimi, I. M., Cutler, D., Stueber, D., and Bujard, H. (1986)
Determinants for protein translocation across mammalian endoplasmic reticulum. Membrane insertion of truncated and full-length prelysozyme molecules,
Eur J Biochem 155, 571-576

Siegel, V., and Walter, P. (1986)
Removal of the Alu structural domain from signal recognition particle leaves its protein translocation activity intact,
Nature 320, 81-84


Tajima, S., Lauffer, L., Rath, V. L., and Walter, P. (1986)
The signal recognition particle receptor is a complex that contains two distinct polypeptide chains,
J Cell Biol 103, 1167-1178

Walter, P., and Lingappa, V. R. (1986)
Mechanism of protein translocation across the endoplasmic reticulum,
Annual Review of Cell Biology 2, 499-516


Moritz, A., Lankat-Buttgereit, B., Gross, H. J., and Goebel, W. (1985)
Common structural features of the genes for two stable RNAs from Halobacterium halobium,
Nucleic Acids Res 13, 31-43

Andrews, D. W., Walter, P., and Ottensmeyer, F. P. (1985)
Structure of the signal recognition particle by electron microscopy,
Proc Natl Acad Sci U S A 82, 785-789

Lauffer, L., Garcia, P. D., Harkins, R. N., Coussens, L., Ullrich, A., and Walter, P. (1985)
Topology of signal recognition particle receptor in endoplasmic reticulum membrane,
Nature 318, 334-338


Zwieb, C. (1985)
The secondary structure of the 7SL RNA in the signal recognition particle: functional implications,
Nucleic acids research 13, 6105-6124


Moritz, A., and Goebel, W. (1985)
Characterization of the 7S RNA and its gene from halobacteria,
Nucleic Acids Res 13, 6969-6979

Siegel, V., and Walter, P. (1985)
Elongation arrest is not a prerequisite for secretory protein translocation across microsomal membranes,
Journal of Cell Biology 100, 1913-1921


Ullu, E., and Weiner, A. M. (1985)
Upstream sequences modulate the internal promoter of the human 7SL RNA gene,
Nature 318, 371-374

von Heijne, G. (1985)
Signal sequences: the limits of variation,
Journal of Molecular Biology 184, 99-105

von Heijne, G. (1985)
Ribosome-SRP-signal sequence interactions. The relay helix hypothesis,
Febs Lett 190, 1-5


Walter, P., Gilmore, R., and Blobel, G. (1984)
Protein translocation across the endoplasmic reticulum,
Cell 38, 5-8


Bonatti, S., Migliaccio, G., Blobel, G., and Walter, P. (1984)
Role of signal recognition particle in the membrane assembly of Sindbis viral glycoproteins,
Eur J Biochem 140, 499-502

Hsu, L. M., Zagorski, J., and Fournier, M. J. (1984)
Cloning and sequence analysis of the Escherichia coli 4.5 S RNA gene,
J Mol Biol 178, 509-531

Gundelfinger, E. D., Di Carlo, M., Zopf, D., and Melli, M. (1984)
Structure and evolution of the 7SL RNA component of the signal recognition particle,
Embo J 3, 2325-2332

Sakaguchi, M., Mihara, K., and Sato, R. (1984)
Signal recognition particle is required for co-translational insertion of cytochrome P-450 into microsomal membranes,
Proc Natl Acad Sci U S A 81, 3361-3364

Jackson, R. J., and Hunt, T. (1983)
Preparation and use of nuclease-treated rabbit reticulocyte lysates for the translation of eukaryotic messenger RNA,
Meth. Enzymol. 96, 50-74


Gundelfinger, E. D., Krause, E., Melli, M., and Dobberstein, B. (1983)
The organization of the 7SL RNA in the signal recognition particle,
Nucleic Acids Res 11, 7363-7374

Gilmore, R., and Blobel, G. (1983)
Transient involvement of signal recognition particle and its receptor in the microsomal membrane prior to protein translocation,
Cell 35, 677-685

Chambers, J. C., Kurilla, M. G., and Keene, J. D. (1983)
Association between the 7 S RNA and the lupus La protein varies among cell types,
J Biol Chem 258, 11438-11441

Meyer, D. I., Krause, E., and Dobberstein, B. (1982)
Secretory protein translocation across membranes - the role of the 'docking protein',
Nature (London) 297, 647-650


Ullu, E., and Melli, M. (1982)
Cloning and characterization of cDNA copies of the 7S RNAs of HeLa cells,
Nucleic Acids Res 10, 2209-2223

Walter, P., and Blobel, G. (1982)
Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum,
Nature 299, 691-698


Walter, P., and Blobel, G. (1981)
Translocation of proteins across the endoplasmic reticulum II. signal recognition protein (srp) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein,
J. Cell Biol. 91, 551-556


Walter, P., and Blobel, G. (1981)
Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site- specific arrest of chain elongation that is released by microsomal membranes,
J Cell Biol 91, 557-561


Walter, P., Ibrahimi, I., and Blobel, G. (1981)
Translocation of proteins across the endoplasmic reticulum: signal recognition protein (srp) binds to in-vitro assembled polysomes synthesizing secretory protein,
J. Cell Biol. 91, 545-550


Walter, P., and Blobel, G. (1980)
Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum,
Proc Natl Acad Sci U S A 77, 7112-7116.

Blobel, G., and Dobberstein, B. (1975)
Transfer to proteins across membranes. II. Reconstitution of functional rough microsomes from heterologous components,
J Cell Biol 67, 852-862

Blobel, G., and Dobberstein, B. (1975)
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma,
J Cell Biol 67, 835-851

Milstein, C., Brownlee, G. G., Harrison, T. M., and Mathews, M. B. (1972)
A possible precursor of immunoglobin light chains,
Nature New Biol 139, 117-120



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