Research group of Tore Samuelsson 

Tore Samuelsson, Professor 
Department of Medical Biochemistry 
University of Goteborg , Medicinareg. 9A
Box 440 , S-405 30 Goteborg, SWEDEN
Tel. + 46 31 786 34 68 , Mob 073 616 9629
Fax + 46 31 41 61 08
Email Tore.Samuelsson@medkem.gu.se

Evolution of RNA and protein genes as studied by comparative genomics.

A huge amount of sequence information is being generated world-wide as part of projects to sequence genomes and transcriptomes of a large number of organisms. This information is a highly valuable source of information to exploit fundamental biological processes such as gene function, transcriptional regulation, and molecular evolution at the level of DNA and protein sequences. Comparative genomics is a science where species are being compared with respect to their genomes, for instance to better understand the evolution of genomes. Comparative genomics is also useful in many computational methods, such as prediction of gene structure, prediction of non-coding RNAs and prediction of regulatory sites in the genome.

We are using comparative genomics and DNA and protein sequence analysis to examine the structure, function and evolution of genes. We have considered protein genes as well as non-coding RNAs (nc-RNA), i.e RNA that do not code for proteins but have other functions. The evolution of proteins is being studied in a number of projects where we make use of tools such as gene prediction, profile-based searches and methods of phylogenetic analysis. We have developed methods to effectively identify ncRNAs in genomic sequences and have applied these methods on a large number of ncRNA families. We have identified a large number of previously unrecognized homologues and these results have allowed a better understanding of the secondary structure and evolution of these RNAs.

RNA bioinformatics    

The evolution of proteins and protein domains.


Recent publications

2015
2014
2013
2012
2011
2010
2009
2008
2007
2006

Previous PhD students

    Marcela Dávila López
    Tiange Lang
    Magnus Alm Rosenblad
    Paul Piccinelli
    Liqun He (co-supervisor)