Research group of Tore Samuelsson 

Tore Samuelsson, Professor 
Department of Medical Biochemistry 
University of Goteborg , Medicinareg. 9A
Box 440 , S-405 30 Goteborg, SWEDEN
Tel. + 46 31 786 34 68 , Mob 073 616 9629
Fax + 46 31 41 61 08

Evolution of RNA and protein genes as studied by comparative genomics.

A huge amount of sequence information is being generated world-wide as part of projects to sequence genomes and transcriptomes of a large number of organisms. This information is a highly valuable source of information to exploit fundamental biological processes such as gene function, transcriptional regulation and molecular evolution. Comparative genomics is a science where genomic features of different organisms are compared. It is used to better understand the evolution of genomes and is also useful in many computational methods, such as prediction of gene structure, prediction of non-coding RNAs and prediction of regulatory sites in the genome.

We are using comparative genomics and DNA and protein sequence analysis to examine the structure, function and evolution of protein genes as well as non-coding RNA (ncRNA) genes. The evolution of proteins is being studied in a number of projects where we make use of tools such as gene prediction, profile-based searches and methods of phylogenetic analysis. We have developed methods to effectively identify ncRNAs in genomic sequences and have applied these methods on a large number of ncRNA families.

Recent publications

Academic textbooks I've authored: