Analysis of gene order conservation in eukaryotes identifies
transcriptionally and functionally linked genes.
Marcela Dávila López1, Juan José Martínez Guerra2 and Tore Samuelsson1*
1Department of Medical Biochemistry and Cell Biology,
Institute of Biomedicine, Sahlgrenska Academy at
University of Gothenburg, Box 440, SE-405 30 Göteborg, Sweden
2Departamento de Química, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes,
Boulevard Universidad 940, C.P. 20100, Aguascalientes, Ags., Mexico
* Corresponding author: Tore.Samuelsson@medkem.gu.se
Submited for publication in PLoS ONE on 22 February 2010
Accepted for publication in PLos ONE on 13 April 2010
Gene order maps as obtained in this work may be accessed at the Eukaryotic Gene Order Browser
eGOB
Figure 1 - Phylogenetic tree of organisms used in this study
Figure 2 - Eukaryotic Gene Order Database (eGOB)
Figure 3 - Evolutionary conservation and relative gene orientation
Figure 4 - Relationship between intergenic distance and evolutionary conservation within the phylogenetic groups Metazoa and Fungi
Figure 5 - Size distribution of intergenic regions in vertebrates
Figure 6 - Functional relationship of pairs of adjacent genes that are evolutionary conserved
Table 1 - List of evolutionary conserved gene pairs as predicted by OrhtoMCL
Table 2 - Ten most conserved human bidirectional gene pairs where only those with an intergenic distance less than 1000 base pares are included
Table S1 - Sources of genomic sequences
Statistics on proteins
Relative gene orientation
Clustering using OrthoMCL and Pfam
Table S2 - All identified pairs of adjacent genes
Table S3 - Intergenic distances characteristic of different species
Table S4 - Pairs of adjacent genes in Metazoa
Table S5 - Potential bidirectional promoters
Figure S1 - Relative orientation of gene pairs
Figure S2 - Distribution of intergenic distances
Figure and Table Legends
Apr 2010, MDL