Analysis of gene order conservation in eukaryotes identifies transcriptionally and functionally linked genes.

Marcela Dávila López1, Juan José Martínez Guerra2 and Tore Samuelsson1*
1Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Box 440, SE-405 30 Göteborg, Sweden
2Departamento de Química, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Boulevard Universidad 940, C.P. 20100, Aguascalientes, Ags., Mexico

* Corresponding author: Tore.Samuelsson@medkem.gu.se


Submited for publication in PLoS ONE on 22 February 2010
Accepted for publication in PLos ONE on 13 April 2010

Gene order maps as obtained in this work may be accessed at the Eukaryotic Gene Order Browser eGOB



Figure 1 - Phylogenetic tree of organisms used in this study

Figure 2 - Eukaryotic Gene Order Database (eGOB)

Figure 3 - Evolutionary conservation and relative gene orientation

Figure 4 - Relationship between intergenic distance and evolutionary conservation within the phylogenetic groups Metazoa and Fungi

Figure 5 - Size distribution of intergenic regions in vertebrates

Figure 6 - Functional relationship of pairs of adjacent genes that are evolutionary conserved


Table 1 - List of evolutionary conserved gene pairs as predicted by OrhtoMCL

Table 2 - Ten most conserved human bidirectional gene pairs where only those with an intergenic distance less than 1000 base pares are included


Table S1 - Sources of genomic sequences
                 Statistics on proteins
                 Relative gene orientation
                 Clustering using OrthoMCL and Pfam

Table S2 - All identified pairs of adjacent genes

Table S3 - Intergenic distances characteristic of different species

Table S4 - Pairs of adjacent genes in Metazoa

Table S5 - Potential bidirectional promoters

Figure S1 - Relative orientation of gene pairs

Figure S2 - Distribution of intergenic distances

Figure and Table Legends



Apr 2010, MDL